Genetic and Molecular Epidemiology Lab

We organize our work into complementary themes:

1. MBL and Risk of CLL Progression

We investigate the prevalence, natural history, and clinical implications of MBL, with a focus on predictors of progression to CLL and associated health outcomes. By identifying individuals at elevated risk, we aim to inform screening and follow up strategies.

2. Genetic Susceptibility and Multi Ancestry Genomics

We conduct large scale genetic studies, integrating cohorts across populations to refine susceptibility loci, evaluate cross ancestry genetic architecture, and build genomic resources that support next generation multi ancestry lymphoma research.

3. Familial CLL and High Risk Populations

We study families with multiple relatives affected by CLL or related lymphoproliferative disorders to clarify inherited risk and early disease markers. This includes screening first degree relatives for MBL and assessing medical history and genetic factors.

4. Immunity, Infections, and Cancer Outcomes

We examine how immune dysregulation and precursor states influence susceptibility to severe infections and other adverse outcomes, integrating epidemiologic, clinical, and molecular data to improve risk assessment.

5. Patient Centered Outcomes and Quality of Life

We investigate quality of life and other patient reported outcomes, including gender differences in the experience of CLL, to ensure that clinical decision making incorporates outcomes that matter to patients.